Dr. Peter Hollenhorst
Associate Professor of Biochemistry and Molecular Biology
Dr. Hollenhorst’s research interest focuses on the mechanisms that allow genome sequence to dictate the transcriptional control of gene expression. The major goal of our laboratory is to understand how genomic binding specificity is achieved in “families” of transcription factors that have homologous DNA binding domains. In particular we focus on the ETS family of oncogenic transcription factors. Chromosomal abnormalities involving ETS transcription factors are found in prostate cancer, Ewing’s sarcoma, and leukemia. We use a wide variety of approaches ranging from biochemistry to genomics to study the interaction of ETS proteins with the genome and to determine the role these mechanisms play in carcinogenesis.
- Selvaraj, N., Kedage, V., and P.C. Hollenhorst. (2015). Comparison of MAPK specificity across the ETS transcription factor family identifies a high-affinity ERK interaction required for ERG function in prostate cells. Cell Communication and Signaling 13:12.
- Selvaraj, N., Budka, J.A., Ferris, M.W., Plotnik, J.P., and P.C. Hollenhorst. (2015). Extracellular signal-regulated kinase signaling regulates the opposing roles of JUN family transcription factors at ETS/AP-1 sites and in cell migration. Molecular and Cellular Biology 35(1): 88-100.
- Plotnik, J.P., Budka, J.A., Ferris, M.W., and P.C. Hollenhorst. (2014). ETS1 is a genome-wide effector of RAS/ERK signaling in epithelial cells. Nucleic Acids Research 42(19): 11928-40.
- Selvaraj, N., Budka, J.A., Ferris, M.W., Jerde, T.J., and P.C. Hollenhorst. (2014). Prostate cancer ETS rearrangements switch a cell migration gene expression program from RAS/ERK to PI3K/AKT regulation. Molecular Cancer 13:61.
- Hollenhorst, P.C. (2012). RAS/ERK pathway transcriptional regulation through ETS/AP-1 binding sites. Small GTPases 1:3.
- Hollenhorst, P.C., Ferris, M.W., Hull, M.A., Chae, H., Kim, S., and B.J. Graves. (2011). Oncogenic ETS proteins mimic activated RAS/MAPK signaling in prostate cells. Genes & Development 25:2147-57.
- Hollenhorst, P.C., McIntosh, L.P., and B.J. Graves. (2011). Genomic and biochemical insights into the specificity of ETS transcription factors. Annual Review of Biochemistry 80: 437-71.
- Hollenhorst, P.C., Paul, L., Ferris, M.W., and B.J. Graves. (2011). The ETS gene ETV4 is required for anchorage-independent growth and a cell proliferation gene expression program in PC3 prostate cells. Genes and Cancer 1: 1044-1052.