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Dr. Tony Neff

Professor Emeritus, Anatomy and Cell Biology

I am currently interested in organ and tissue regeneration in amphibians with emphasis on limb regeneration.   I am particularly interested in the process of reprogramming (dedifferentiation) during limb regeneration and the role of the immune system in modulating the regeneration process.  

Representative Publications

  • Mescher AL, Neff AW, King MW.  (2013) Changes in the inflammatory response to injury and its resolution during the loss of regenerative capacity in developing Xenopus limbs.  PLoS One. 8(11):e80477.
  • King, M. W., A. W. Neff, and A. L. Mescher (2012) The developing Xenopus limb as a model for studies on the balance between inflammation and regeneration. (Anatomical Record, in press). 
  • King, M.W., A.W. Neff, and A.L. Mescher (2009) Proteomics analysis of regenerating amphibian limbs: Changes during the onset of regeneration.  Internat. J. Devel. Biol. 53: 955-969. 
  • Werner SR, Mescher AL, Neff AW, King MW, Chaturvedi S, Duffin KL, Harty MW, Smith RC. (2007) Neural MMP-28 expression precedes myelination during development and peripheral nerve repair.  Dev Dyn.  Sep 6; [Epub ahead of print] 
  • Mescher AL,Wolf WL, Moseman EA, Hartman B, Harrison C, Nguyen E, and Neff AW (2007) Cells of cutaneous im.munity in Xenopus: Studies during larval development.  Developmental and Comparative Immunology 31:383-393. 
  • Grow MW, Neff AW, Mescher AL, King MW. (2006) Global analysis of gene expression in Xenopus limbs during stage-dependent complete and incomplete regeneration. Dev. Dyn. 235:2667-2685. 
  • Neff AW, King MW, Harty MW, Nguyen T, Calley J, Smith RC, Mescher AL. (2005) Expression of Xenopus XlSALL4 during limb development and regeneration.  Dev Dyn. 233(2):356-367 
  • Mescher AL, Neff AW (2005). Regenerative capacity and the developing immune system. Adv. Biochemical Engineering/ Biotechnology 93:39-66. 
  • Neff AW, King MW, Harty MW, Nguyen T, Calley J, Smith RC, Mescher AL. (2005) Expression of Xenopus XlSALL4 during limb development and regeneration.  Dev Dyn. 233(2):356-367. 
  • Mescher AL, Neff AW (2005). Regenerative capacity and the developing immune system. Adv. Biochemical Engineering/ Biotechnology 93: 39-66. 
  • Mescher AL, Neff AW (2004). Loss of regenerative capacity: A trade-off for immune specificity?  Cellscience (on-line Cellscience.com/reviews2) 
  • Goh E, Neff AW (2003).  Effects of Fluoride on Xenopus embryo development; Food Chem Toxicol 41:1501-1508 
  • Harty, M., A.W. Neff, M.W. King, and A.L. Mescher (2003) Regeneration or scarring: An immunologic perspective. Devel. Dynamics 226: 268-279. 
  • King, M.W., T. Nguyen, J. Calley, M.W. Harty, M.C. Muzinich, A.L. Mescher, C. Chalfant, M. N’Cho, K. McLeaster, J. McEntire, D. Stocum, R.C. Smith, and A.W. Neff. (2003) Identification of genes expressed during Xenopus laevis limb regeneration by using subtractive hybridization. Devel. Dynamics 226: 398-409. 
  • Martin G, Goh E, Neff AW. (2002) Evaluation of the developmental toxicity of crocetin on Xenopus. Food and Chemical Toxicology; 40:959-964. 
  • Krishnan  P, King MW, Neff AW, Sandusky GE, Bierman KL, Grinnell B  and  Smith RC  (2001) Human truncated Smad 6 (Smad 6s) inhibits the BMP pathway in Xenopus laevis.  Dev Growth Differ 43:115-132.

  • NEWS
  • SEMINARS
  • EVENTS
  • Microenvironment-induced downregulation of miR-193b drives ovarian cancer metastasis

    Apr 28th, 2015

    Anirban K Mitra, Assistant Professor of Medical and Molecular Genetics has recently published his research in Oncogene. His study links paracrine signals from the microenvironment to the regulation of a key miRNA - miR-193b - in ovarian cancer cells, which promotes metastatic colonization.

    New link between motor proteins and breast cancer

    Apr 21th, 2015

    Collaborative work between Claire Walczak (Medical Sciences) and Ritu Aneja (Georgia Tech) reveals that overexpression of the mitotic kinesin, HSET, promotes tumor progression.

    American Cancer Society awards Research Scholar Grant to Dr. Heather Hundley

    Apr 21th, 2015

    Heather A. Hundley, Assistant Professor of Biochemistry and Molecular Biology, has been awarded a $775,000 grant from the American Cancer Society to support her project “Mechanisms Regulating RNA Editing at Specific Sites in the Transcriptome.”

    PUBLICATION

    Comparison of MAPK specificity across the ETS transcription factor family identifies a high-affinity ERK interaction required for ERG function in prostate cells

    Selvaraj N, Kedage V, Hollenhorst PC

    ERK signaling regulates the opposing roles of JUN family transcription factors at ETS/AP-1 sites and in cell migration

    Selvaraj N, Budka JA, Ferris MW, Plotnik JP, Hollenhorst PC

    Regulatory mechanisms that control mitotic kinesins

    Yount AL, Zong H, Walczak CE

  • Peter Hollenhorst, PhD

    Aug. 31, 4pm JH 009

    Assistant Professor of Biochemistry and Molecular Biology Medical Sciences Program,
    Indiana University Bloomington, IN

    Lindsey D. Mayo, PhD

    Sept. 14, 4pm JH 009

    Associate Professor of Pediatrics
    Associate Professor of Biochemistry and Molecular Biology Wells Center for Pediatric Research
    Indianapolis, IN

    Charles N. Landen Jr, MD

    Sept. 21, 4pm JH 009

    Associate Professor
    Department of Obstetrics and Gynecology
    University of Virginia Cancer Center

    Qianben Wang, PhD

    Sept. 28, 4pm JH 009

    Associate Professor
    Department of Molecular Virology, Immunology and Medical Genetics and the Comprehensive Cancer Center
    College of Medicine the Ohio State University

  • CME conference

    Ethical Decisions for End of Life Care

    Wednesday, Jul 8th

    Shawn Gerber, M.Div.
    BCC Director, Spiritual Care & Chaplaincy IU Health Bloomington
    Bloomington, IN

    Pediatric Trauma

    Friday, Jul 10th

    Yueh Chang Ho, MD
    Assistant Prof. of Radiology
    IUSOM
    Indianapolis, IN

    Carpal Tunnel Syndrome

    Wednesday, Jul 15th

    Otto Wickstrom, MD
    IU Health Southern Indiana Physicians
    Orthopedics & Sports Medicine
    Bloomington, IN

    Personalized Medicine: Challenges to Patients & their Physicians

    Friday, Jul 24th

    Kenneth Cornetta, MD
    IU Dept. of Medical & Molecular Genetics

    The Increasing Complexity of Venous Thromboembolic Disease

    Friday, Jul 31st

    Kenneth Cornetta, MD
    David Hedrick, MD

    Indiana Hemophilia & Thrombosis Center
    Indianapolis, IN

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