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Research

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Labs

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Daleke Lab

We study molecular mechanisms controlling phospholipid organization in biological membranes, with an emphasis on the effects of diabetes on membrane lipid organization and the characterization and identification of phospholipid transporters, or "flippases."

daleked@indiana.edu

Dr. Daleke’s lab webpage

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Hollenhorst Lab

We use genomics and bioinformatics approaches to study the mechanisms that ETS family transcription factors use to interact with the genome in an effort to delineate both normal and oncogenic functions of these proteins.

pchollen@indiana.edu

Dr. Hollenhorst’s lab webpage

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Mitra Lab

Our lab seeks to understand the paracrine and juxtacrine interactions between cancer cells and their microenvironment that regulate metastatic colonization in ovarian cancer with a specific interest in the regulation of key microRNAs and transcription factors.

anmitra@indiana.edu

Dr. Mitra’s lab webpage

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O’Hagan Lab

Our lab studies the role of oxidative DNA damage in initiating cancer-specific epigenetic changes. We examine chromatin changes that occur acutely during DNA repair and how the persistence of these changes may lead to heritable changes in gene expression.

hmohagan@indiana.edu

Dr. O’Hagan’s lab webpage

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Walczak Lab

Our lab is interested in the molecular mechanisms that govern mitotic spindle assembly and chromosome segregation in both normal and tumor-derived cells. We are developing screening assays to identify new drugs that target microtubule assembly.

cwalczak@indiana.edu

Dr. Walczak’s lab webpage

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Foley Lab

Our lab studies the epithelial-mesenchyme interactions in the repair and regeneration of specialized skin of the nipple. We intend to use the information gained from our basic studies to develop a cell-based regeneration nipple strategy for mastectomy victims.

jgfoley@indiana.edu

Dr. Foley’s lab webpage

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Hundley Lab

Our lab is interested in post-transcriptional regulation of gene expression. We utilize a combination of biochemistry, genomics and molecular biology to identify the molecular mechanisms that regulate RNA editing and the consequences of aberrant editing on gene expression.

hahundle@indiana.edu

Dr. Hundley’s lab webpage

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Nephew Lab

We are using microarray technology and mathematical models to explore the role of epigenetics in ovarian cancer cells and resistance to chemotherapy. We also study breast cancer, estrogen receptor biology, and resistance to antiestrogens.

knephew@indiana.edu

Dr. Nephew’s lab webpage

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Suthers Lab

We are interested in the neural basis of behavior, particularly the neuroethology of acoustic communication. My research is primarily focused on the physiology of song production in songbirds and parrots.

suthers@indiana.edu

Dr. Suthers’ lab webpage

  • NEWS
  • SEMINARS
  • EVENTS
  • Microenvironment-induced downregulation of miR-193b drives ovarian cancer metastasis

    Apr 28th, 2015

    Anirban K Mitra, Assistant Professor of Medical and Molecular Genetics has recently published his research in Oncogene. His study links paracrine signals from the microenvironment to the regulation of a key miRNA - miR-193b - in ovarian cancer cells, which promotes metastatic colonization.

    New link between motor proteins and breast cancer

    Apr 21th, 2015

    Collaborative work between Claire Walczak (Medical Sciences) and Ritu Aneja (Georgia Tech) reveals that overexpression of the mitotic kinesin, HSET, promotes tumor progression.

    American Cancer Society awards Research Scholar Grant to Dr. Heather Hundley

    Apr 21th, 2015

    Heather A. Hundley, Assistant Professor of Biochemistry and Molecular Biology, has been awarded a $775,000 grant from the American Cancer Society to support her project “Mechanisms Regulating RNA Editing at Specific Sites in the Transcriptome.”

    PUBLICATION

    Comparison of MAPK specificity across the ETS transcription factor family identifies a high-affinity ERK interaction required for ERG function in prostate cells

    Selvaraj N, Kedage V, Hollenhorst PC

    ERK signaling regulates the opposing roles of JUN family transcription factors at ETS/AP-1 sites and in cell migration

    Selvaraj N, Budka JA, Ferris MW, Plotnik JP, Hollenhorst PC

    Regulatory mechanisms that control mitotic kinesins

    Yount AL, Zong H, Walczak CE

  • Peter Hollenhorst, PhD

    Aug. 31, 4pm JH 009

    Assistant Professor of Biochemistry and Molecular Biology Medical Sciences Program,
    Indiana University Bloomington, IN

    Lindsey D. Mayo, PhD

    Sept. 14, 4pm JH 009

    Associate Professor of Pediatrics
    Associate Professor of Biochemistry and Molecular Biology Wells Center for Pediatric Research
    Indianapolis, IN

    Charles N. Landen Jr, MD

    Sept. 21, 4pm JH 009

    Associate Professor
    Department of Obstetrics and Gynecology
    University of Virginia Cancer Center

    Qianben Wang, PhD

    Sept. 28, 4pm JH 009

    Associate Professor
    Department of Molecular Virology, Immunology and Medical Genetics and the Comprehensive Cancer Center
    College of Medicine the Ohio State University

  • CME conference

    Ethical Decisions for End of Life Care

    Wednesday, Jul 8th

    Shawn Gerber, M.Div.
    BCC Director, Spiritual Care & Chaplaincy IU Health Bloomington
    Bloomington, IN

    Pediatric Trauma

    Friday, Jul 10th

    Yueh Chang Ho, MD
    Assistant Prof. of Radiology
    IUSOM
    Indianapolis, IN

    Carpal Tunnel Syndrome

    Wednesday, Jul 15th

    Otto Wickstrom, MD
    IU Health Southern Indiana Physicians
    Orthopedics & Sports Medicine
    Bloomington, IN

    Personalized Medicine: Challenges to Patients & their Physicians

    Friday, Jul 24th

    Kenneth Cornetta, MD
    IU Dept. of Medical & Molecular Genetics

    The Increasing Complexity of Venous Thromboembolic Disease

    Friday, Jul 31st

    Kenneth Cornetta, MD
    David Hedrick, MD

    Indiana Hemophilia & Thrombosis Center
    Indianapolis, IN

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