We study molecular mechanisms controlling phospholipid organization in biological membranes in health and disease, with an emphasis on the effects of diabetes on membrane lipid organization and the characterization and identification of phospholipid transporters, or "flippases."
Our lab studies the molecules that mediate hormonal control of skin development and how these factors contribute to cancer cell destruction of bone.
In the Hollenhorst lab we study the mechanisms that ETS family transcription factors use to interact with the genome in an effort to delineate both normal and oncogenic functions of these proteins.
Our lab is interested in understanding how structured regions within mRNAs, specifically within the 3’ untranslated region (3’ UTR) affect gene expression.
We are interested in the cellular interactions required for tissue and organ regeneration and the focus of our work is the regenerating amphibian limb, which is able to regenerate completely following amputation. Current work involves an analysis of gene expression during the period when regeneration begins and how this gene activity is regulated by factors released during inflammation.
The Walczak lab is interested in the molecular mechanisms that govern mitotic spindle assembly and chromosome segregation in both normal and tumor-derived cells.