We study molecular mechanisms controlling phospholipid organization in biological membranes, with an emphasis on the effects of diabetes on membrane lipid organization and the characterization and identification of phospholipid transporters, or "flippases."
We use genomics and bioinformatics approaches to study the mechanisms that ETS family transcription factors use to interact with the genome in an effort to delineate both normal and oncogenic functions of these proteins.
Our lab seeks to understand the paracrine and juxtacrine interactions between cancer cells and their microenvironment that regulate metastatic colonization in ovarian cancer with a specific interest in the regulation of key microRNAs and transcription factors.
Our lab studies the role of oxidative DNA damage in initiating cancer-specific epigenetic changes. We examine chromatin changes that occur acutely during DNA repair and how the persistence of these changes may lead to heritable changes in gene expression.
Our lab is interested in the molecular mechanisms that govern mitotic spindle assembly and chromosome segregation in both normal and tumor-derived cells. We are developing screening assays to identify new drugs that target microtubule assembly.
Our lab studies the epithelial-mesenchyme interactions in the repair and regeneration of specialized skin of the nipple. We intend to use the information gained from our basic studies to develop a cell-based regeneration nipple strategy for mastectomy victims.
Our lab is interested in post-transcriptional regulation of gene expression. We utilize a combination of biochemistry, genomics and molecular biology to identify the molecular mechanisms that regulate RNA editing and the consequences of aberrant editing on gene expression.
We are using microarray technology and mathematical models to explore the role of epigenetics in ovarian cancer cells and resistance to chemotherapy. We also study breast cancer, estrogen receptor biology, and resistance to antiestrogens.
Our lab studies directed cell migration during metazoan development. Abnormal cell migration can lead to the spread of cancer cells. We apply genetic, molecular and genomic approaches to the study cell migration, using the small, experimentally tractable nematode C. elegans.
Educational Research Group
The Educational Research Group is interested in the scholarship of teaching and learning with undergraduate students, graduate students, and medical students. We endeavor to evaluate and further implement evidence-based teaching practices at all levels of health science education.